ICR Publications

Members of the Integrated Cancer Research Group have reported their work in the following international publications
over the past five years:

Key Publications

2008 Publications

2007 Publications

2006 Publications

2005 Publications

2004 Publications

2003 Publications

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Key Publications

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2008 Publications

Segditsas S, Sieber OM, Rowan A, Setien F, Neale K, Phillips RK, Ward R, Esteller M, Tomlinson IP. Promoter hypermethylation leads to decreased APC mRNA expression in familial polyposis and sporadic colorectal tumours, but does not substitute for truncating mutations. Exp Mol Pathol (2008) In press:.

Packham D, Ward RL, Lin VA, Hawkins NJ, Hitchins MP. Implementation of novel pyrosequencing assays to screen for common mutations of BRAF and KRAS in a cohort of sporadic colorectal cancers. Diagn Mol Pathol (2008) In press:.

Ringland C, Mant A, McGettigan P, Mitchell P, Kelman C, Buckley N, Pearson SA. Uncovering the potential risk of serotonin toxicity in Australian veterans using pharmaceutical claims data. Brit J Clin Pharmaco (2008) In press:.

Wakefield CE et al including Ward R. A randomized controlled trial of a decision aid for women considering genetic testing for breast and ovarian cancer risk. Breast Cancer Res and Treat (2008) 107:289-301.

Webster LR, Lee SF, Ringland C, Morey AL, Hanby AM, Morgan G, Byth K, Mote PA, Provan PJ, Ellis IO, Green AR, Lamoury G, Ravdin P, Clarke CL, Ward RL, Balleine RL, Hawkins NJ. Poor-prognosis estrogen receptor-positive breast cancer identified by histopathologic subclassification. Clin Cancer Res (2008) 14(20):6625-6633.

Weber MF, Banks E, Ward R, Sitas F. Population characteristics related to colorectal cancer testing in New South Wales, Australia: results from the 45 and Up Study cohort. J Med Screen (2008) 15:137-142.

Wakefield CE, Meiser B, Homewood J, Ward R, O’Donnell S, Kirk J, Australian GENetic testing Decision Aid Collaborative Group. Randomized trial of a decision aid for individuals considering genetic testing for hereditary nonpolyposis colorectal cancer risk. Cancer (2008) 113:956-965.

Wakefield CE, Meiser B, Homewood J, Taylor A, Gleeson M, Williams R, Tucker K; Australian GENetic testing Decision Aid Collaborative Group (Ward R et al). A randomized trial of a breast/ovarian cancer genetic testing decision aid used as a communication aid during genetic counseling. Psycho Oncol (2008) 17(8):844-854.

Monk M, Hitchins M, Hawes S. Differential expression of the embryo/cancer gene ECSA(DPPA2), the cancer/testis gene BORIS and the pluripotency structural gene OCT4, in human pre-implantation development. Mol Hum Reprod (2008) 34:347-355.

Lu C, Ross-Degnan D, Soumerai S, Pearson S. Interventions designed to improve the quality and efficiency of medication use in managed care: a critical review of the literature – 2001-2007. BMC Health Serv Res (2008) 8:75.

De Sanjose S, Benavente Y, Vajdic CM, Engels E, Morton L, Bracci PM, Spinelli JJ, Zheng T, Zwang Y, Franceschi S, Talamini R, Holly EA, Grulich AE, Cerhan JR, Hartge P, Cozen W, Boffetta P, Brennan P, Maynadié M, Cocco P, Bosch R, Foretova L et al. Hepatitis C and risk of non-Hodgkin lymphoma (NHL): a pooled analysis of 4,784 cases and 6,269 controls from the InterLymph Consortium. Clin Gastroenterol Hepatol (2008) 6:451-458.

Ekström Smedby K, Vajdic CM, Falster MO, Grulich AE, Engels E, Martinez-Maza O, Turner J, Hjalgrim H, Vineis P, Seniori Costantini A, Holly EA, Bracci PM, Willett E, Spinelli J, Dal Maso L, Zheng T, Becker N, de Sanjosé S, Chiu B, Cocco P et al. Autoimmune disorders and risk of non-Hodgkin lymphoma: a pooled analysis within the InterLymph Consortium. Blood (2008) 111:4029-4038.

Playford E G, Marriott D, Nguyen Q, Chen S, Ellis D, Slavin M and Sorrell T. Candidemia in nonneutropenic critically ill patients: Risk factors for non-albicans Candida spp. Crit Care Med (2008) 36 (7):2034-2039.

Troke P, Aguirrebengoa K, Arteaga C, Ellis D, Heath C, Lutsar I, Rovira M, Nguyen Q, Slavin M, Chen S and the Global Scedosporium Study Group. Treatment of scedosporiosis with voriconazole: Clinical experience with 107 patients. Antimicrob Agents Ch (2008) May:1743-1750.

2007 Publications

Lane C, Ho T, Healy T, Pearson S, Brown M. How to attract a nephrology trainee: Quantitative questionnaire results. Nephrology (2007) 13:116-123.

Pimanda JE, Ottersbach K, Knezevic K, Kinston K, Chan W, Wilson N, Wood A, Landry JR, Kolb-kokocinski A, Green AR, Tannahill D, Lacaud G, Kouskoff V and Gottgens B. Gata2, Fli1 and Scl form a recursively wired gene regulatory circuit in developing blood stem cells. Proc Natl Acad Sci (2007) Nov 6; 104(45):17692-7.

Pimanda JE, Donaldson IJ, De Bruijn MFTR, Kinston S, Knezevic K, Huckle L, Piltz S, Landry JR, Green AR, Tannahill DT and Göttgens B. The SCL transcriptional network and the BMP signaling pathway interact to regulate RUNX1 activity. Proc Natl Acad Sci (2007) Jan 16;104(3):840-5.

Chan WYI, Follows GA, Lacaud G, Pimanda JE, Landry JR, Kinston S, Knezevic, Piltz S, Donaldson IJ, Green AR, Kouskoff V, Gottgens B. Haematopoietic and endothelial expression of the paralogue bHLH transcription factors Lyl1 and Scl/Tal1 is jointly controlled by Ets and GATA factors yet Lyl1 cannot rescue the SCL ^-/- phenotype. Blood (2007) Mar 1;109(5):1908-16.

Hitchins MP, Ward RL. Addendum: Germline epimutation of MLH1 in individuals with multiple cancers. Nat Genet (2007) 39:1414.

Hitchins MP, Ward RL. Erasure of MLH1 methylation in spermatozoa - implications for epigenetic inheritance. Nat Genet (2007) 39:1289.

Van Gool K, Gallego G, Haas M, Viney R, Hall J, Ward R. Economic evidence at the local level - options for making it more useful. Pharmacoeconomics (2007) 25(12):1055-1062.

Hitchins MP, Lin VA, Buckle A, Cheong K, Halani N, Ku S, Kwok CT, Packham D, Suter CM, Meagher A, Stirzaker C, Clark S, Hawkins NJ, Ward RL. Epigenetic inactivation of a cluster of genes flanking MLH1 in microsatellite-unstable colorectal cancer. Cancer Res (2007) 67(19):9107-9116.

Easton DF, Pooley KA, et al, Ward R et al, Webb P. Genome-wide association study identifies novel breast cancer susceptibility loci. Nature (2007) 447:1087-1093.

Heinzelmann-Schwarz VA, Scolyer RA, Scurry JP, Smith AN, Gardiner-Garden M, Biankin AV, Baron-Hay S, Scott C, Ward RL, Fink D, Hacker NF, Sutherland RL, O'Brien PM. Low meprin á expression differentiates primary ovarian mucinous carcinoma from gastrointestinal cancers that commonly metastasise to the ovaries. J Clin Pathol (2007) 60:622-626.

More H, Humar B, Weber W, Ward R, Christian A, Lintott C, Graziano F, Ruzzo A.M, Acosta E, Boman B, Harlan M, Ferreira P, Seruca R, Suriano G, Guilford P. Identification of seven novel germline mutations in the human E-cadherin (CDH1) gene. Hum Mutat (2007) 28:203-11.

Pearson S, Ringland C, Ward R. Trastuzumab and metastatic breast cancer: Trastuzumab use in Australia - Monitoring the effect of an expensive medicine access program. J Clin Oncol (2007) 25:3688-3693.

Hettiaratchi A, Hawkins NJ, McKenzie G, Ward RL, Hunt JE, Wakefield D, Di Girolamo N. The collagenase-1 (MMP-1) gene promoter polymorphism - 1607/2G is associated with favourable prognosis in patients with colorectal cancer. Br J Cancer (2007) 96:783-792.

Hitchins MP, Wong JJL, Suthers G, Suter CM, Martin DIK, Hawkins NJ, Ward RL. Inheritance of a cancer-associated MLH1 germ-line epimutation. N Engl J Med (2007) 356:697-705.

Ioannidis JPA, Ahmed T, Awasthi S, Clarfield AM, Clark J, Dandona L, Howe A, Lozano JM, Li Y, Madani H, Marusic A, Mohammed I, Purcell GP, Rhoads M, Sliwa-Hahnle K, Straus SE, Edejer TT-T, Tugwell P, Ward R, Wilkes MS, Smith R. Open letter to the leader of academic medicine. Brit Med J (2007) 334:191-193.

Wong JJ, Hawkins NJ, Ward RL. Colorectal cancer: a model for epigenetic tumorigenesis. Gut (2007) 56:140-148.

The SAFE study Investigators. Resuscitation with saline compared to albumin in traumatic brain injury. N Engl J Med (2007) 357:874-884.

Kelman CW, Pearson SA, Day RO, Holman CD, Kliewer EV, Henry DA. Evaluating medicines: let's use all the evidence. Med J Aust (2007) 186:249-252.

Correll PK, Xuan W, Williamson M, Sundararajan V, Ringland C, Marks GB. Reattendance at hospital for asthma in two Australian states, 2000-2003. Respirology (2007) 12:220-226.

Mant A, Lowinger J, Hall W, Whicker S, Ringland C, Stark H. Statins down under. Br J Clin Pharmacol (2007) 63:125-127.

Pearson S, Ringland C, Kelman CW, Mant A, Lowinger JS, Stark H, Nicholls G, Day RO, Henry DA. Patterns of analgesic and anti-inflammatory medicine use by Australian veterans. Intern Med J (2007) 37:798-805.

Faedo M, Hinds LA, Singleton GR, Rawlinson W. Prevalence of Mouse Mammary Tumor Virus (MMTV) in wild house mice (MUS DOMESTICUS) in Southeastern Australia. J Wildlife Dis (2007) In press:.

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2006 Publications

Johnson KR, Ringland C, Stokes BJ, Anthony DM, Freemantle N, Irs A, Hill SR, Ward RL. Response rate or time to progression as predictors of survival in trials of metastatic colorectal cancer or non-small-cell lung cancer: a meta-analysis. Lancet Oncol (2006) 7:741-746.

Gazarian M, Kelly M, McPhee JR, Graudins LV, Ward RL, Campbell TJ. Off-label use of medicines: consensus recommendations for evaluating appropriateness. Med J Aust (2006) 185:544-548.

Colebatch A, Hitchins M, Williams R, Meagher A, Hawkins NJ, Ward RL. The role of MYH and microsatellite instability in the development of sporadic colorectal cancer. Br J Cancer (2006) 95:1239-1243.

Brown DA, Stephan C, Ward RL, Law M, Hunter M, Bauskin AR, Amin J, Jung K, Diamandis EP, Hampton GM, Russell PJ, Giles GG, Breit SN. Measurement of serum levels of macrophage inhibitory cytokine 1 combined with prostate-specific antigen improves prostate cancer diagnosis. Clin Cancer Res (2006) 12:89-96.

Tan EL, Stark H, Lowinger JS, Ringland C, Ward R, Pearson SA. Information sources used by New South Wales cancer clinicians: a qualitative study. Intern Med J (2006) 36:711-717.

Kang HH, Williams R, Leary J, Ringland C, Kirk J, Ward R. Evaluation of models to predict BRCA germline mutations. Br J Cancer (2006) 95:914-920.

Hitchins M, Suter C, Wong J, Cheong K, Hawkins N, Leggett B, Scott R, Spigelman A, Tomlinson I, Martin D, Ward R. Germline epimutations of APC are not associated with inherited colorectal polyposis. Gut (2006) 55:586-587.

Pearson SA, Soumerai S, Mah C, Zhang F, Simoni-Wastila L, Salzman C, Cosler LE, Fanning T, Gallagher P, Ross-Degnan D. Racial disparities in access after regulatory surveillance of benzodiazepines. Arch Intern Med (2006) 166:572-579.

Ringland C, Correll PK, Lim K, Williamson M, Marks GB. Hospital readmissions for asthma: a feasibility study comparing strategies for linking hospital morbidity data. Aust New Zeal J Publ Health (2006) 30:435-439.

Chow SSW, Craig ME, Jacques CFH, Hall B, Catteau J, Munro SC, Scott GM, Camaris C, McIver CJ, Rawlinson WD. Correlates of placental infection with cytomegalovirus, parvovirus B19 or human herpes virus 7. J Med Virol (2006) 78:747-756.

Schneppenheim R, Kremer Hovinga JA, Becker T, Budde U, Karpman D, Brockhaus W, Hrachovinova I, Korczowski B, Oyen F, Rittich S, von Rosen J, Tjonnfjord GE, Pimanda JE, Wienker TF, Lammle B. A common origin of the 4143insA ADAMTS13 mutation. Thromb Haemost (2006) Jul; 96(1): 3-6.

Pimanda JE, Silberstein L, Dominici M, Dekel B, Bowen M, Oldham S, Kallianpur A, Brandt S, Tannahill D, Gottgens B, Green AR. Transcriptional link between blood and bone: the stem cell leukaemia gene and its +19 stem cell enhancer are active in bone cells. Mol Cell Biol (2006) Apr; 26(7): 2615-25

Pimanda JE, Chan WYIC, Donaldson IJ, Bowen M, Green AR, Gottgens B. Endoglin expression in the endothelium is regulated by Fli-1, Erg, and Elf-1 acting on the promoter and a -8-kb enhancer. Blood (2006) Jun 15; 107(12): 4737-45.

2005 Publications

Martin DI, Ward R, Suter CM. Germline epimutation: a basis for epigenetic disease in humans. Ann N Y Acad Sci (2005) 1054:68-77.

Clark J. Five futures for academic medicine: the ICRAM scenarios. Brit Med J (2005) 331:101-104.

Awasthi S, Beardmore J, Clark J, Hadridge P, Madani H, Marusic A, Purcell G, Rhoads M, Sliwa-Hahnle K, Smith R, Edejer TT, Tugwell P, Underwood T, Ward R. Five futures for academic medicine. PLoS Med (2005) 2:e207.

Hitchins M, Williams R, Cheong K, Halani N, Lin VA, Packham D, Ku S, Buckle A, Hawkins N, Burn J, Gallinger S, Goldblatt J, Kirk J, Tomlinson I, Scott R, Spigelman A, Suter C, Martin D, Suthers G, Ward R. MLH1 germline epimutations as a factor in hereditary nonpolyposis colorectal cancer. Gastroenterology (2005) 129:1392-1399.

Ward RL, Turner J, Williams R, Pekarsky B, Packham D, Velickovic M, Meagher A, O'Connor T, Hawkins NJ. Routine testing for mismatch repair deficiency in sporadic colorectal cancer is justified. J Pathol (2005) 207:377-384.

Liauw W, Segelov E, Lih A, Dunleavy R, Links M, Ward R. Off-trial evaluation of bisphosphonates in patients with metastatic breast cancer. BMC Cancer (2005) 5:89.

Hall WD, Ward R, Liauw WS, Lu CY, Brien JA. Tailoring access to high cost, genetically targeted drugs. Assessment of real cost effectiveness, with data linked to individual health outcomes while protecting patient privacy, is an essential challenge we need to meet. Med J Aust (2005) 182:607-608.

Tothill RW, Kowalczyk A, Rischin D, Bousioutas A, Haviv I, van Laar RK, Waring PM, Zalcberg J, Ward R, Biankin AV, Sutherland RL, Henshall SM, Fong K, Pollack JR, Bowtell DD, Holloway AJ. An expression-based site of origin diagnostic method designed for clinical application to cancer of unknown origin. Cancer Res (2005) 65:4031-4040.

Kairupan CF, Meldrum CJ, Crooks R, Milward EA, Spigelman AD, Burgess B, Groombridge C, Kirk J, Tucker K, Ward R, Williams R, Scott RJ. Mutation analysis of the MYH gene in an Australian series of colorectal polyposis patients with or without germline APC mutations. Int J Cancer (2005) 116:73-77.

Ward R, Liauw W, Segelov E, Links M. Clinical practice and skeletal event rates. Brit Med J (2005) 330:769-773.

Meagher AP, Ward RL. Re: Evidence supports adjuvant radiotherapy in selected patients with rectal cancer. ANZ J Surg (2005) 74:1123-1124.

Grulich AE, Cunningham P, Munier ML, Prestage G, Amin J, Ringland C, Whitby D, Kippax S, Kaldor JM, Rawlinson W. Sexual behaviour and human herpesvirus 8 infection in homosexual men in Australia. Sex Health (2005) 2:13-18.

Petoumenos K, Ringland C, Australian HIVOD. Antiretroviral treatment change among HIV, hepatitis B virus and hepatitis C virus co-infected patients in the Australian HIV Observational Database. HIV Med (2005) 6:155-163.

Trincado DE, Munro SC, Camaris C, Rawlinson WD. Highly sensitive detection and localization of maternally acquired human cytomegalovirus in placental tissue by in situ polymerase chain reaction. J Infect Dis (2005) 192:650-657.

Munro SC, Hall B, Whybin LR, Leader L, Robertson P, Maine GT, Rawlinson WD. Diagnosis of and screening for cytomegalovirus infection in pregnant women. J Clin Microbiol (2005) 43:4713-4718.

Munro SC, Trincado D, Hall B, Rawlinson WD. Symptomatic infant characteristics of congenital cytomegalovirus disease in Australia. J Paediatr Child Health (2005) 41:449-452.

Munro SC. Viruses in the placenta. Microbiology Australia (2005) 26:19-21.

McIver CJ, Jacques CFH, Chow SSW, Munro SC, Scott GM, Roberts JA, Craig ME, Rawlinson WD. Development of multiplex PCRs for detection of common viral pathogens and agents of congenital infections. J Clin Microbiol (2005) 43:5102-5110.

Rainis L, Toki T, Pimanda JE, Rosenthal E, Machol K, Strehl S, Gottgens B, Ito E, Izraeli S. The proto-oncogene ERG in megakaryoblastic leukemias. Cancer Res (2005) Sep 1;65(17):7596-602.

2004 Publications

Wilkinson D, Ward RL. International Campaign to Revitalise Academic Medicine (ICRAM): what does it mean for Australia?. Med J Aust (2004) 181:658-659.

Awasthi S, Beardmore J, Clark J, Hadridge P, Madani H, Marusic A, Purcell G, Rhoads M, Sliwa-Hahnle K, Smith R, Edejer TT, Tugwell P, Underwood T, Ward R. Academic medicine: the evidence base. Brit Med J (2004) 329:789-792.

Awasthi S, Beardmore J, Clark J, Hadridge P, Madani H, Marusic A, Purcell G, Rhoads M, Sliwa-Hahnle K, Smith R, Edejer TT, Tugwell P, Underwood T, Ward R. ICRAM (the International Campaign to Revitalise Academic Medicine): agenda setting. Brit Med J (2004) 329:787-789.

Ward RL, Williams R, Law M, Hawkins NJ. The CpG island methylator phenotype is not associated with a personal or family history of cancer. Cancer Res (2004) 64:7618-7621.

Morgan G, Ward R, Barton M. The contribution of cytotoxic chemotherapy to 5-year survival in adult malignancies. Clin Oncol (R Coll Radiol) (2004) 16:549-560.

Suter CM, Martin DI, Ward RL. Germline epimutation of MLH1 in individuals with multiple cancers. Nat Genet (2004) 36:497-501.

Ward RL, Mokany E. Germline testing of mismatch repair genes is not aided by prescreening tumours for allelic loss. Gut (2004) 53:471-472.

Suter CM, Martin DI, Ward RL. Hypomethylation of L1 retrotransposons in colorectal cancer and adjacent normal tissue. Int J Colorectal Dis (2004) 19:95-101.

Lomas M, Liauw W, Packham D, Williams K, Kelleher A, Zaunders J, Ward R. Phase I clinical trial of a human idiotypic p53 vaccine in patients with advanced malignancy. Ann Oncol (2004) 15:324-329.

Kumar RK, Hawkins NJ, Harris P, Velan GM. Bridging the gap between the scientific and societal aspects of medical education. JIAMSE (2004) 14:015-17.

Hitchins MP, Rickard S, Dhalla F, Fairbrother UL, de Vries BB, Winter R, Pembrey ME, Malcolm S. Investigation of UBE3A and MECP2 in Angelman syndrome (AS) and patients with features of AS. Am J Med Genet A (2004) 125:167-172.

Rolfe IE, Ringland C, Pearson SA. Graduate entry to medical school? Testing some assumptions. Med Educ (2004) 38:778-786.

Ringland C, Taylor L, Bell J, Lim K. Demographic and socio-economic factors associated with dental health among older people in NSW. Aust New Zeal J Publ Health (2004) 28:53-61.

Martin A, Smith DE, Carr A, Ringland C, Amin J, Emery S, Hoy J, Workman C, Doong N, Freund J, Cooper DA, Mitochondrial Toxicity Study G. Reversibility of lipoatrophy in HIV-infected patients 2 years after switching from a thymidine analogue to abacavir: the MITOX Extension Study. AIDS (2004) 18:1029-1036.

The SAFE study Investigators. (Writing Committee: Finfer S, Bellomo R, Boyce N, French J, Myburgh J, Norton R). A comparison of albumin and saline for fluid resuscitation in the intensive care unit. N Engl J Med (2004) 350:2247-2256.

Ford CE, Faedo M, Rawlinson WD. Mouse mammary tumor virus-like RNA transcripts and DNA are found in affected cells of human breast cancer. Clin Cancer Res (2004) 10:7284-7289.

Ford CE, Faedo M, Crouch R, Lawson JS, Rawlinson WD. Progression from normal breast pathology to breast cancer is associated with increasing prevalence of mouse mammary tumor virus-like sequences in men and women. Cancer Res (2004) 64:4755-4759.

Ford C, Faedo M, Delprado W, Rawlinson W. Correspondence re: C. Ford, et al. Mouse mammary tumor virus-like gene sequences in breast tumors of Australian and Vietnamese women. Clin. Cancer Res., 9: 1118-1120, 2003. Clin Cancer Res (2004) 10:802.

Faedo M, Ford CE, Mehta R, Blazek K, Rawlinson WD. Mouse mammary tumor-like virus is associated with p53 nuclear accumulation and progesterone receptor positivity but not estrogen positivity in human female breast cancer. Clin Cancer Res (2004) 10:4417-4419.

Ahren D, Faedo M, Rajashekar B, Tunlid A. Low genetic diversity among isolates of the nematode-trapping fungus Duddingtonia flagrans: evidence for recent worldwide dispersion from a single common ancestor. Mycological Research (2004) 108:1205-1214.

Pimanda JE, Genderton T, Lawler J, Kershaw G, Maekawa A, Chesterman CN, Hogg PJ. Role of Thrombospondin 1 in control of von Willebrand Factor multimer size in mice. J Biol Chem (2004) May 14; 279(20) 21439-21448.

Pimanda JE, Maekawa A, Wind T, Paxton J, Chesterman CN, Hogg PJ. Congenital Thrombotic Thrombocytopenic Purpura in association with a mutation in the second CUB domain of ADAMTS13. Blood (2004) Jan 15; 103(2) 627-631.

2003 Publications

Quinn E, Hawkins N, Yip YL, Suter C, Ward R. CD103+ intraepithelial lymphocytes--a unique population in microsatellite unstable sporadic colorectal cancer. Eur J Cancer (2003) 39:469-475.

Ward RL, Cheong K, Ku SL, Meagher A, O'Connor T, Hawkins NJ. Adverse prognostic effect of methylation in colorectal cancer is reversed by microsatellite instability. J Clin Oncol (2003) 21:3729-3736.

Ward R. Anti-neoplastic antibodies-clinical applications. Australian Prescriber (2003) 26:141-143.

Grieu F, Malaney S, Ward R, Joseph D, Iacopetta B. Lack of association between CCND1 G870A polymorphism and the risk of breast and colorectal cancers. Anticancer Res (2003) 23:4257-4259.

Norrie MW, Hawkins NJ, Todd AV, Meagher AP, O'Connor TW, Ward RL. Inactivation of p16INK4a by CpG hypermethylation is not a frequent event in colorectal cancer. J Surg Oncol (2003) 84:143-150.

Brown DA, Ward RL, Buckhaults P, Liu T, Romans KE, Hawkins NJ, Bauskin AR, Kinzler KW, Vogelstein B, Breit SN. MIC-1 serum level and genotype: associations with progress and prognosis of colorectal carcinoma. Clin Cancer Res (2003) 9:2642-2650.

Andreyev HJ, Benamouzig R, Beranek M, Clarke P, Cunningham D, Norman AR, Giaretti W, de Goeij AF, Iacopetta BJ, Jullian E, Krtolica K, Lee JQ, Wang ST, Lees N, Al-Mulla F, Muller O, Pauly M, Pricolo V, Russo A, Troungos C, Urosevic N, Ward R. Mutant K-ras2 in serum. Gut (2003) 52:915-916.

Welsh JB, Sapinoso LM, Kern SG, Brown DA, Liu T, Bauskin AR, Ward RL, Hawkins NJ, Quinn DI, Russell PJ, Sutherland RL, Breit SN, Moskaluk CA, Frierson HF Jr., Hampton GM. Large-scale delineation of secreted protein biomarkers overexpressed in cancer tissue and serum. Proc Natl Acad Sci U S A (2003) 100:3410-3415.

Bariol C, Suter C, Cheong K, Ku SL, Meagher A, Hawkins N, Ward R. The relationship between hypomethylation and CpG island methylation in colorectal neoplasia. Am J Pathol (2003) 162:1361-1371.

Yip YL, Novotny J, Edwards M, Ward RL. Structural analysis of the ErbB-2 receptor using monoclonal antibodies: Implications for receptor signalling. Int J Cancer (2003) 104:303-309.

Bariol C, Hawkins NJ, Turner JJ, Meagher AP, Williams DB, Ward RL. Histopathological and clinical evaluation of serrated adenomas of the colon and rectum. Mod Pathol (2003) 16:417-423.

Suter CM, Norrie M, Ku SL, Cheong KF, Tomlinson I, Ward RL. CpG island methylation is a common finding in colorectal cancer cell lines. Brit J Cancer (2003) 88:413-419

Patel P, Weerasekera N, Hitchins M, Boyd CA, Johnston DG, Williamson C. Semi quantitative expression analysis of MDR3, FIC1, BSEP, OATP-A, OATP-C,OATP-D, OATP-E and NTCP gene transcripts in 1st and 3rd trimester human placenta. Placenta (2003) 24:39-44.

Quinn E, Hawkins N, Yip YL, Suter C, Ward R. CD103+ intraepithelial lymphocytes--a unique population in microsatellite unstable sporadic colorectal cancer. Eur J Cancer (2003) 39:469-475.

Arnaud P, Monk D, Hitchins M, Gordon E, Dean W, Beechey CV, Peters J, Craigen W, Preece M, Stanier P, Moore GE, Kelsey G. Conserved methylation imprints in the human and mouse GRB10 genes with divergent allelic expression suggests differential reading of the same mark. Hum Mol Genet (2003) 12:1005-1019.

Pearson SA, Ross-Degnan D, Payson A, Soumerai SB. Changing medication use in managed care: a critical review of the available evidence. Am J Manag Care (2003) 9:715-731.

Pimanda JE, Chesterman CN, Hogg PJ. A Perspective on the Measurement of ADAMTS13 in Thrombotic Thrombocytopaenic Purpura. European Journal of Haematology (2003) Apr; 70 (4):257-62.

Pimanda JE, Lowe HC, Hogg PJ, Chesterman CN, Kachigian LM. Novel and emerging therapies in cardiology and haematology. Current Drug Targets- Cardiovascular & Haematological Disorders (2003) 3 (2):101-123